β-NGF / Beta-NGF Protein (Native)

• ≥1mg Bulk:  Inquiring Price

Related Areas:

Neuroscience>>Neurotrophic Factor & Receptor>>Neurotrophin & Receptor>>NGF

Cancer>>Growth Factor & Receptor>>Neurotrophin & Receptor>>NGF

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
NGF/NGFB	Human	NGF Protein, Recombinant	11050-HNAC
NGF/NGFB	Mouse	NGF Protein, Recombinant	50385-MNAC

Antibodies:

As the first one of a series of neurotrophic factors, nerve growth factor (NGF) is important for the development and maintenance of the sympathetic and sensory nervous systems. NGF was identified as a large complex consisting of three non-covalently linked subunits, α, β, and γ, among which, the β subunit, called β-NGF, was demonstrated to exhibits the growth stimulating activity of NGF. β-NGF is a target-derived secreted homodimeric protein of two 120-amino acid mature polypeptides after proteolytic removal of the signal and pro peptide. NGF acts via at least two receptors on the surface of cells, TrkA and p75 receptors to regulate neuronal survival, promote neurite outgrowth, and up-regulate certain neuronal functions such as mediation of pain and inflammation. In additon to its neurotropic activities, studies indicated that NGF may also have an important role in the regulation of the immune system. The synthesis of β-NGF in astrocytes is enhanced by various other cytokines including IL-1, TNF-α , PDGF and TGF-β .Defects in β-NGF are the cause of hereditary sensory and autonomic neuropathy type 5 (HSAN5) characterized by degeneration of dorsal root and autonomic ganglion cells, as well as sensory and/or autonomic abnormalities.

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